Key insights

• ⚡ Initial excitement for en supplements was based on mouse studies showing improved energy levels, muscle performance, and resilience against disease
• 📅 First human study on en supplements was published in February 2020
• 🐭 Recent mouse studies did not show lifespan extension, but suggested delayed age-associated decline and onset of frailty in mice
• ⚗️ More human trials needed to validate potential benefits of en supplements
• 🐭 Study on mice showed lifespan extension in females but not males
• 👵 Potential benefits of enmen on age-related decline
• 🤔 Challenges of relying on customer reviews and the placebo effect
• ⚕️ Importance of clinical trials to determine true treatment effectiveness

Q&A

• What caution is advised with vitamin B3 supplementation?

  Caution is advised with vitamin B3 supplements as high doses may increase mortality rates and worsen blood vessel inflammation. Long-term safety concerns exist, and it's recommended not to supplement with vitamin B3 beyond 50mg.

• What is emphasized in the video regarding the analysis of supplement studies?

  It's important to carefully analyze the raw data and compare it to placebos when evaluating supplement studies to draw accurate conclusions about their effectiveness.

• What did most human studies indicate about inim supplements and metabolic health?

  Most human studies on inim supplements showed no improvement in muscle performance and metabolic health, suggesting limited benefits from such supplementation.

• What is recommended to support muscle NAD levels according to recent research?

  Exercise and a healthy diet may support muscle NAD levels, potentially indicating alternative approaches to improving muscle performance.

• What does recent research suggest about the effectiveness of NMN supplements?

  Recent research suggests that NMN supplements appear safe over the short-term, increase blood NAD, but do not significantly improve muscle NAD or performance.

• What did the study on mice show about lifespan extension in relation to en supplements?

  The study on mice showed lifespan extension in females but not males, indicating potential gender-specific effects of en supplements.

• Why is there a need for more human trials related to en supplements?

  More human trials are needed to validate the potential benefits of en supplements and assess their effectiveness in humans.

• What did recent mouse studies reveal about en supplements?

  Recent mouse studies did not show lifespan extension, but suggested delayed age-associated decline and onset of frailty in mice.

• When was the first human study on en supplements published?

  The first human study on en supplements was published in February 2020.

• What was the initial excitement for en supplements based on?

  The initial excitement for en supplements was based on mouse studies showing improved energy levels, muscle performance, and resilience against disease.

• 00:00 After reviewing 18 human studies of enmen supplements, it was found that initial excitement for en supplements stemmed from mouse studies indicating improved energy levels, muscle performance, and resilience against disease. The first human study was published in February 2020, and despite the lack of human research at the time, many people started taking enem supplements based on the promising mice studies. However, recent studies with mice did not show lifespan extension, but suggested delayed age-associated decline and onset of frailty in mice. The excitement for en supplements is based on early research, with more human trials needed to validate potential benefits.
• 02:17 The video discusses a study on mice showing lifespan extension in females but not males, potential benefits of enmen on age-related decline, challenges of relying on customer reviews, and the importance of clinical trials to determine true treatment effectiveness.
• 04:28 Supplements like NMN appear safe over the short-term, increase blood NAD, but do not significantly improve muscle NAD or performance. Recent research suggests that exercise and a healthy diet can support muscle NAD levels. The effectiveness of NMN supplements in improving muscle performance remains uncertain.
• 06:37 Most human studies on inim supplements showed no improvement in muscle performance and metabolic health. There were some controversial results in one study, but overall, the evidence does not support significant benefits from inim supplementation. Exercise and a healthy diet are likely more effective for improving NAD levels and metabolic health.
• 08:52 Enzyme supplements may not significantly improve metabolic health or energy levels, and the results of studies on insulin sensitivity, sleep, fatigue, and arterial stiffness are inconclusive. It's important to carefully analyze the raw data and compare to placebos when evaluating supplement studies.
• 11:02 Be cautious with vitamin B3 supplements as high doses may increase mortality rates. Studies suggest potential harm from excessive vitamin B3 intake including worsening blood vessel inflammation. Limited evidence supports the benefits of NMN supplements, and long-term safety concerns exist. It's advised not to supplement with vitamin B3 beyond 50mg. Prioritize exercise for health.