Key insights

• Impact of Oxalates

  • 🔄 Oxalates are naturally present in the body and have various mechanisms for removal.
  • 🍽️ Cooking vegetables, consuming calcium or citrate, and managing free oxalate content can help reduce the negative impact of oxalates.
  • 🔬 Research on oxalate content is challenging due to variability in values and limited testing by food companies.
  • 💊 Calcium and magnesium can bind to oxalates in the gut, preventing absorption into the body.

• Keto Citra for Kidney Health

  • ⚛️ Keto Citra combines beta hydroxy butyrate and citrate for synergistic effect.
  • 💎 Aims to prevent crystal formation and increase alkalinity in urine.
  • 🍶 Potassium and alkali are beneficial for kidney function.
  • 🍃 Oxalates can cause free radical damage to kidneys.

• Positive Effects of Ketone Bodies and Ketone Salts

  • ⚡ Ketone bodies aid in energy production through mitochondrial effect.
  • 📝 They interact with transcription factors to promote fatty acid metabolism.
  • 🚫 Inhibit NLRP3 inflammasome, reducing inflammation.
  • ⏱️ Ketone salts may have rapid positive effects on kidney health.
  • 🔬 Santa Barbara Nutrients developed Ketone salts tailored for kidney health based on this research.

• Role of Ketone Bodies in Polycystic Kidney Disease (PKD)

  • 🧬 Polycystic kidney disease (PKD) is a genetic form of chronic kidney disease characterized by rapid cyst accumulation.
  • 🌀 Mitochondrial dysfunction and inflammation contribute to PKD progression.
  • 🛡️ BHB (ketone) may have anti-inflammatory effects that could help prevent PKD progression by influencing immune cells.

• Functions of Ketones in Kidneys

  • 🔬 Ketones have multiple functions beyond energy production.
  • 👌 The kidneys are the second organ that produces ketones.
  • 📈 Efficiency in ketone production may increase in a nutritional ketogenic state.
  • 🔄 Potential retention of efficiency and improved kidney function after cycling off a ketogenic diet.
  • 🔋 BHB may increase mitochondrial density in the kidneys.

• Low Carb Diet and Kidney Function

  • 💪 Low carb diet can affect fluid regulation and lead to muscle cramps.
  • 🍞 Possible connection between glucose, sodium, and potassium balance in low carb state.
  • ❓ Misconceptions about ketosis and kidney health.
  • 🧠 Understanding the role of ketones in different parts of the nephron and their impact on kidney function.

• Regulation of Fat Accumulation by Kidneys

  • 💧 The kidneys regulate fat accumulation based on serum fat concentration.
  • 🔥 Ketones can impact chronic kidney disease and provide an alternative fuel source for the kidneys.
  • ⚗️ Keto Citra can potentially slow the progression of chronic kidney disease, bind to harmful dietary components, and help stop the formation of microcrystals.
  • ⚠️ Under deranged conditions, fat accumulation can lead to inflammation and other complications.

• Metabolic Health and Kidneys

  • ⚖️ Metabolic health involves all organs and maintaining balance and homeostasis.
  • 🗣️ Constant communication between different organ systems is crucial for metabolic health.
  • 🔑 Key levers impacting metabolic health include glucose, fats, and not eating, as well as various molecules.
  • 👩‍⚕️ The kidneys play a significant role in overall metabolism, consuming a lot of energy, regulating fat metabolism, and maintaining balance in the blood.

Q&A

• What are oxalates and how can their buildup be managed?

  Oxalates are naturally present in the body and can lead to health issues when built up. Managing oxalate buildup involves cooking vegetables, consuming calcium or citrate, and managing free oxalate content.

• How was Keto Citra developed to improve kidney health?

  Keto Citra was developed to improve kidney health by combining beta hydroxy butyrate and citrate to prevent crystal formation, increase alkalinity in urine, and provide energetic, anti-inflammatory benefits.

• What are the positive effects of ketone bodies on kidney health?

  Ketone bodies have positive effects on energy production, fatty acid metabolism, and inflammation, potentially improving kidney health and providing rapid benefits.

• What is polycystic kidney disease (PKD)?

  Polycystic kidney disease (PKD) is a genetic form of chronic kidney disease characterized by the rapid accumulation of cysts on the kidneys, leading to a decline in kidney function and eventual renal failure. Mitochondrial dysfunction and inflammation contribute to PKD progression.

• What functions do ketones have beyond energy production?

  Ketones have various functions beyond energy production, including potential contributions to improved kidney function, increased mitochondrial density, and anti-inflammatory effects.

• How do ketones impact kidney function?

  Ketones can impact chronic kidney disease, provide an alternative fuel source for the kidneys, potentially slow the progression of kidney disease, and have varying impacts on different parts of the nephron.

• What role do the kidneys play in metabolism?

  The kidneys play a significant role in overall metabolism by consuming a lot of energy, regulating fat metabolism, and maintaining balance in the blood. They also regulate fat accumulation based on serum fat concentration and can act as a repository for fats.

• What does metabolic health involve?

  Metabolic health involves maintaining balance and homeostasis among all organs, with constant communication between different organ systems. Key levers impacting metabolic health include glucose, fats, and various molecules.

• 00:00 Metabolic health involves all organs and is about maintaining balance and homeostasis. Every tissue participates in metabolism, and there is constant communication between different organ systems. Key levers impacting metabolic health include glucose, fats, and not eating, as well as various molecules. The kidneys play a significant role in overall metabolism, consuming a lot of energy, regulating fat metabolism, and maintaining balance in the blood.
• 06:17 The kidneys regulate fat accumulation based on serum fat concentration, with fat droplet accumulation being associated with high serum fat levels. Ketones can impact chronic kidney disease and provide an alternative fuel source for the kidneys. Keto Citra can potentially slow the progression of chronic kidney disease, bind to harmful dietary components, and help stop the formation of micr crystals. The kidneys can act as a repository for fats and regulate fat levels for energy needs, but under deranged conditions, fat accumulation can lead to inflammation and other complications.
• 12:49 Discussion on the impact of low carb diet and kidney function, including the link between cramping and fluid regulation, and the effect of ketones on the kidneys. Ketosis is not inherently bad for the kidneys; ketones have varying impacts on different parts of the nephron.
• 18:46 Ketones have various functions beyond energy production, including in the kidneys, where they are produced and may contribute to improved kidney function. The kidneys are the second organ that produces ketones, and it's likely that they become more efficient at ketone production in a nutritional ketogenic state. Retaining efficiency in ketone production and potential kidney function after cycling off a ketogenic diet is possible. Mitochondrial density in the kidneys may increase with BHB, and similar effects can be achieved through timed feeding, periodic fasting, or exogenous ketone supplementation.
• 24:48 Polycystic kidney disease (PKD) is a genetic form of chronic kidney disease characterized by the rapid accumulation of cysts on the kidneys, leading to a decline in kidney function and eventual renal failure. Cysts result from an injury response and typically do not go away, causing a loss of kidney function. Mitochondrial dysfunction and inflammation contribute to PKD progression, but BHB (ketone) may have anti-inflammatory effects that could help prevent PKD progression by influencing immune cells.
• 31:00 Ketone bodies have positive effects on energy production, fatty acid metabolism, and inflammation. They can potentially improve kidney health, and their benefits may be seen rapidly. Santa Barbara Nutrients has used this research to develop Ketone salts specifically for kidney health.
• 37:23 Keto Citra was developed to improve kidney health by combining beta hydroxy butyrate and citrate to create a synergistic effect. It aims to prevent crystal formation, increase alkalinity in urine, and provide energetic, anti-inflammatory benefits. Potassium and alkali are important for kidney function, and oxalates can cause free radical damage.
• 43:50 Oxalates are common in the body and can be found in various tissues, and their build-up can lead to health issues. Cooking vegetables, consuming calcium or citrate, and managing free oxalate content can help reduce oxalate buildup. Research on oxalate content is challenging due to variability in values and limited testing.