Key insights

• Subjective Experiences and Health Impacts

  • 🏷️ Subjective experiences of cannabis heavily influenced by labeling and user expectations
  • ❓ Lack of conclusive evidence on the health effects of cannabis use
  • ⚠️ Potential risks and benefits for health highlighted, emphasizing the need for research

• Cannabis Use and Mental Health

  • 🧠 Association between high THC cannabis use and psychosis, and the link with schizophrenia
  • 💭 The complex relationship between cannabis use and schizophrenia
  • 🧬 Influence of genetic vulnerability on the onset of schizophrenia

• Public Health and Legalization Impact

  • ⚖️ Changes in cannabis use patterns and ER visits due to unintended pediatric consumption
  • 👶 Different effects of edibles and inhalants on the body and their impact on hormones
  • 🤰 Potential impact on pregnancy and public health concerns

• Impacts and Risks of Cannabis Use

  • 🍔 Cannabis leading to high food-seeking behavior and impacting cognitive function
  • 🧠 Challenges with titrating the amount of intake and cannabis use disorder
  • ⚕️ Effects on hormones, sperm quality, and fertility

• Biological Effects of Cannabis

  • 🌱 Discussion about the biology of cannabis and its medical applications
  • 🔬 THC activating CB1 receptors leading to intoxicating effects, unlike endocannabinoids
  • 💡 Strategies to increase endocannabinoid activity without ingesting THC
  • 💊 Cannabis effects involving active compounds beyond the endocannabinoid system

Q&A

• What are the potential benefits of cannabis use?

  Potential benefits of cannabis use include anxiety and pain management, but the video emphasizes the complexity of cannabis use and the need for additional research.

• What are the potential risks associated with cannabis use?

  Cannabis use may pose risks for lung damage, cardiovascular issues, cyclic vomiting syndrome, and psychosis. Additionally, the lack of conclusive evidence regarding its health effects is highlighted.

• Is there a correlation between cannabis use and the prevalence of schizophrenia?

  The prevalence of schizophrenia doesn't seem to correlate with cannabis use rates. Genetic studies suggest that people with a genetic risk for schizophrenia are more likely to use cannabis, rather than the correlation being the other way around.

• What is the relationship between cannabis use and schizophrenia?

  The video discusses the complex relationship between cannabis use and schizophrenia, including the potential increased risk for psychosis with high THC cannabis usage, the impact of genetic vulnerability, and differing perspectives on causality and stressors.

• What is the conversion rate to developing cannabis use disorder, and what are the impacts of legalization?

  The conversion rate to developing cannabis use disorder is around 30% for weekly users. Legalization of cannabis has led to changes in use patterns and unintended pediatric consumption of edibles, resulting in visits to the ER.

• What are some potential effects of cannabis use?

  Cannabis use can impact food-seeking behavior, focus, memory, and psychology. It may also lead to cannabis use disorder, impact hormones, and affect sperm quality and fertility.

• How do endocannabinoids differ from THC in their effects?

  Endocannabinoids such as Anandamide and 2-AG have distinct properties and roles in the brain, acting in specific spatial and temporal manners. In contrast, THC from cannabis activates CB1 receptors indiscriminately, leading to intoxicating effects.

• What topics are discussed in the video?

  The video covers various topics related to cannabis, including its biology, medical applications, potential harms, the effects of THC versus CBD, the state of being high, the role of endocannabinoids in the brain, and more.

• 00:00 The episode is a discussion about cannabis and its effects, featuring Dr. Matthew Hill. They explore topics such as the biology of cannabis, its medical applications, its potential harms, the effects of THC versus CBD, the state of being high, and the role of endocannabinoids in the brain.
• 29:12 The endocannabinoids, Anandamide and 2-AG, have distinct properties and roles in the brain. Anandamide might act as a tonic molecule, regulating steady states, while 2-AG is involved in rapid and on-demand regulation. THC from cannabis indiscriminately activates CB1 receptors, leading to intoxicating effects, unlike endocannabinoids which act in a specific spatial and temporal manner. Strategies to increase endocannabinoid activity without ingesting THC include the use of FA inhibitors. The effects of cannabis involve various active compounds, not just the endocannabinoid system.
• 57:37 The use of cannabis can lead to high food seeking behavior, potentially due to the activation of receptors normally activated during a fasting state. Cannabis use can impact focus, memory, and psychology, but evidence on its effects on long-term cognitive function is not compelling. Users tend to titrate the amount of intake to achieve similar blood levels of THC, especially with lower potency cannabis, while concentrates pose challenges due to their high THC content. Cannabis can lead to cannabis use disorder, which can consume a person's life and lead to behaviors similar to those seen in other substance use disorders.
• 01:26:25 The conversion rate to developing cannabis use disorder is around 30% for weekly users. Legalization of cannabis has led to changes in use patterns and ER visits due to unintended pediatric consumption of edibles. Edibles and inhalants have different effects on the body due to dosing and metabolism. Cannabis usage impacts hormones, including prolactin and testosterone, but the effects are mixed and not conclusively understood. Cannabis usage may also affect sperm quality and fertility.
• 01:55:14 The video segment discusses the varying levels of cannabis use during pregnancy, potential effects on the developing fetus, irresponsible recommendations at dispensaries, public health concerns, high THC cannabis and psychosis, and the complex relationship between cannabis use and schizophrenia.
• 02:24:56 The prevalence of schizophrenia doesn't seem to correlate with cannabis use rates. Genetic studies suggest that people with a genetic risk for schizophrenia are more likely to use cannabis, and not the other way around. Cannabis labels and user expectations may heavily influence subjective experiences, and it's difficult to scientifically isolate the impact of specific strains or compositions of the plant.
• 02:54:56 The speaker discusses various aspects of CBD, cannabis, and potential health implications. CBD may not produce significant biological effects at low doses, and its effects are mostly attributed to placebo. Cannabis use may pose risks for lung damage, cardiovascular issues, and postural hypotension. The speaker highlights the lack of conclusive evidence regarding the health effects of cannabis use.
• 03:23:57 The discussion sheds light on cannabis effects, including potential risks such as cardiovascular impacts, cyclic vomiting syndrome, and psychosis, as well as potential benefits for anxiety and pain management. It highlights the complexity of cannabis use and the need for additional research. The episode emphasizes the importance of open discussions and collaboration in advancing scientific understanding.