Key insights

• Importance of Behavioral Factors

  • 🛡️ Supplements are viewed as an insurance policy and not a necessity for healthspan and lifespan
  • 💤 The significance of exercise, sleep, nutrition, and emotional health over supplements
  • 💬 Explanation of individual supplement regimens and their rationale
  • 📊 Importance of new data to change their stance on supplementation

• Epigenome, Radiation, and Aging Process

  • 🧬 Challenges in measuring and sequencing the epigenome
  • ☢️ Radiation exposure from various sources and its relationship to health risks
  • 👴🏼 The aging process and the need to work hard to preserve vitality in later years
  • ⚡ Changing energy levels as part of the aging process
  • 🏋️ The influence of exercise timing on energy levels throughout the day
  • 💊 Use of supplements and their potential benefits

• Supplements and FDA Rulings

  • 💊 The sale of supplements like NMN and NR impacted by FDA rulings
  • ❌ Lack of strong arguments for taking NMN
  • 🧪 Challenges associated with biologic aging tests
  • 📏 Limitations of biologic aging measurements and their predictability of longevity

• NR vs. NMN and Glycemic Control

  • 🍽️ Tight glycemic control independently of weight can contribute to longevity
  • 🔍 Molecules have withstood ITP scrutiny and met a high bar for lifespan experiments
  • 💊 Commercial battle between NR and NMN supplements, with FDA designation and claims about bioavailability
  • 📉 Insignificant benefits of NR and NMN for age-related health, with statistically significant but clinically insignificant findings
  • 📚 Sticky debate in the longevity field about taking a substance to extend lifespan

• NAD and Lifespan

  • 🔄 NADH facilitates transfer of chemical energy to electrical energy and back to chemical energy
  • 📉 NAD levels decline with age, but supplementing NAD lacks scientific evidence for longevity benefits
  • 💡 Different forms of NAD supplementation have practical considerations and unclear benefits in terms of lifespan
  • 🐭 Rigorous testing in mice has shown limited success in extending lifespan with NAD supplementation

• Ceran Activation and NAD Levels

  • 🍄 Ceran overexpression in yeast may lead to increased lifespan, independent of caloric restriction
  • 🐁 Transgenic mice overexpressing ceran showed a lifespan increase, with males living 10-15% longer
  • 👴🏼 Decline in NAD levels with age, especially in the skin, and its potential implications on tissue health
  • 🍇 Resveratrol, a ceran activator, had mixed results in lifespan extension experiments

• mTOR Inhibition and Caloric Restriction

  • 🔬 mTOR inhibition through rapamycin shows uniform life extension in various organisms, making it a significant intervention
  • 🔥 Potential synergies and conflicts between rapamycin and caloric restriction are uncertain and require further study
  • 🐶 Ongoing studies on rapamycin's impact on lifespan, including a dog aging study and trials in mammals, will provide valuable insights
  • ⚡ NAD is essential for energy production and mitochondrial pathways, regulating numerous cellular processes
  • 🧬 Cerin uses NAD as a substrate for DNA repair, highlighting its importance in cellular function and longevity
  • ❓ Challenges and uncertainties surround the impact of caloric restriction on lifespan in humans, with potential trade-offs between reducing chronic diseases and increasing other health risks

• Approaches to Longevity

  • ⏳ Behavioral factors, disease-specific molecules, geroprotective molecules, and a combination of approaches
  • 🧠 Impact of emotional health on longevity
  • 💊 Dr. Atia's exogenous molecule intake for disease-specific and geroprotective purposes

Q&A

• How do the guests view the significance of supplements for healthspan and lifespan?

  The guests emphasize the significance of exercise, sleep, nutrition, and emotional health over supplements. While sharing their individual supplement regimens, they underscore the need for new data to change their stance on supplementation, viewing supplements as an insurance policy rather than a necessity for healthspan and lifespan.

• What other topics are covered in the video?

  The video covers a range of topics, including challenges in measuring and sequencing the epigenome, radiation exposure, the aging process and its impact on vitality and energy levels, the influence of exercise timing on energy levels, and the use of supplements and their potential benefits.

• What are the issues surrounding the sale of supplements like NMN and NR?

  The video discusses the impact of FDA rulings on the sale of supplements like NMN and NR. It also delves into the lack of strong arguments for taking NMN and the challenges associated with biologic aging tests, as well as the limitations of biologic age measurements and their predictability of longevity.

• What is the discussion about tight glycemic control and molecules like NR and NMN?

  Tight glycemic control, regardless of weight, is noted to contribute to longevity. The commercial battle between NR and NMN supplements, their equivalence, and the core question of their impact on lifespan and health span is highlighted. The video also covers the lack of strong arguments for taking NR and NMN and their insignificant benefits for age-related health.

• What is the significance of NADH and NAD supplementation in relation to longevity?

  NADH facilitates the transfer of chemical energy in our bodies, and the decline in NAD levels with age is noted. Different forms of NAD supplementation are discussed, highlighting practical considerations and limited success in extending lifespan through rigorous testing in mice.

• What is the potential role of ceran activation in lifespan extension?

  The discussion explores the potential role of ceran activation in lifespan extension, with focus on yeast and transgenic mouse studies. It also covers the link between ceran activation, NAD levels, DNA repair, the effects of resveratrol, and the decline in NAD levels with age, especially in the skin.

• How does NAD affect aging and longevity?

  NAD is essential for energy production and mitochondrial pathways, regulating numerous cellular processes. Its decline with age, along with the potential synergies and conflicts with caloric restriction, is discussed. Additionally, the significance of NAD in DNA repair and its potential impact on longevity is explored.

• What is the importance of mTOR and rapamycin in relation to aging?

  mTOR inhibition through rapamycin shows uniform life extension in various organisms, making it a significant intervention. Experimental data supports its impact on life extension, and ongoing studies, including a dog aging study and trials in mammals, will provide valuable insights.

• What are the different approaches to longevity discussed in the video?

  The video discusses various approaches to longevity, including behavioral factors, disease-specific molecules, geroprotective molecules, and a combination of approaches. It also touches on the impact of emotional health on longevity and shares Dr. Atia's intake of exogenous molecules for disease-specific and geroprotective purposes.

• 00:00 The episode discusses approaches to longevity, including behavioral factors, molecules for disease, geroprotective molecules, and a combination of approaches. The podcast also touches on the impact of emotional health on longevity. Dr. Atia shares the exogenous molecules he takes, including those targeting specific diseases and for geroprotection.
• 18:53 The discussion covers the importance of mTOR and experimental data supporting its impact on life extension, the potential synergies and conflicts with caloric restriction, ongoing studies on the impact of rapamycin, the role of NAD in energy production and mitochondrial pathways, the significance of cerin in DNA repair, and the challenges of conducting caloric restriction experiments in humans.
• 37:59 The discussion delves into the activation of ceran and its potential role in lifespan extension, with a focus on yeast and transgenic mouse studies. It also explores the link between ceran activation, NAD levels and DNA repair, as well as the effects of resveratrol as a ceran activator. The decline in NAD levels with age is highlighted, along with its potential impact on various tissues, especially the skin.
• 57:15 NADH is crucial for facilitating the transfer of chemical energy to electrical energy and back to chemical energy in our bodies through the electron transport chain. NAD levels decline with age, but supplementing NAD is not straightforward and lacks scientific evidence for longevity benefits. Different forms of NAD supplementation, such as intravenous NAD, NR, and NMN, have practical considerations and may not show clear benefits in terms of lifespan. Rigorous testing in mice has shown limited success in extending lifespan with NAD supplementation.
• 01:16:40 Tight glycemic control regardless of weight contributes to longevity; molecules withstood the ITP scrutiny; commercial battle between NR and NMN; insignificant benefits for age-related health; NR and NMN are equivalent; debate overlooks the core question of their impact on lifespan and health span.
• 01:35:45 The video segment discusses the issues surrounding the sale of supplements such as NMN and NR, the impact of FDA rulings, the lack of strong arguments for taking NMN, and the challenges associated with biologic aging tests. The conversation also delves into the limitations of biologic age measurements and the difficulty of predicting longevity based on such measurements.
• 01:54:30 The segment discusses the challenges of measuring and sequencing the epigenome, radiation exposure from various sources, the aging process and its impact on vitality, energy levels, and the influence of exercise timing on energy levels. The conversation also covers the use of supplements and their potential benefits.
• 02:11:44 A comprehensive discussion on supplement intake and the importance of behavioral factors for healthspan and lifespan. Both guests emphasize the significance of exercise, sleep, nutrition, and emotional health over supplements. They share their individual supplement regimens but emphasize the need for new data to change their stance on supplementation. Supplements are viewed as an insurance policy and not a necessity for healthspan and lifespan.